Advisors
Now showing items 1-14 of 14
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Analysis of differentially expressed geExpression of notch signaling pathway recenes in breast cancer : BRCA1- induced gene expression profiles and meta-analysis gene signature
(Bilkent University, 2009)The aim of the first part of this study was to find out the expression profiles of the genes, which were selected from the former BRCA1-induced gene list (OVCA1, OVCA2, ERBIN, RAD21, XRN2, RENT2, SMG1 and MAC30) in ... -
Analysis of tumor suppressor genes in testis cancer
(Bilkent University, 1998)At least two classes of genes are involved directly or indirectly in the regulation of cell growth and differentiation. One group of these genes, known as tumor suppressor genes, is involved in cellular regulation by ... -
Development of a non-immunological system for the study of the cellular localization of BRCA1 gene product in living cells
(Bilkent University, 1997)BRCAl, is a familial breast and ovarian cancer susceptibility gene that has been cloned and shown to be either lost or mutated in families with breast and ovarian cancer. BRCAl, has been postulated to encode a tumor ... -
Discovery of novel agents for liver cancer therapeutics and characterization of their bioactivities on cellular pathways
(Bilkent University, 2015-12)Hepatocellular carcinoma is the second deadliest and fifth most common cancer type worldwide. Due to the limited therapy options, it is crucial to develop novel targeted therapeutic agents that provide better prognosis ... -
Effects of biological compound Turkish propolis extract on breast cancer cells
(Bilkent University, 2013)Propolis is a resinous compound which is collected from various plants then combined with wax and bee enzymes by worker bees. There are many studies conducted on propolis or its active components aiming to find new ... -
Functional effects of ATAD2 gene expression in breast cancer
(Bilkent University, 2016-08)The ATAD2 gene is a newly investigated gene of which the expression levels are associated with the disease prognosis in many types of cancer and especially breast cancer and that is known to be overexpressed usually through ... -
Gene expression profiling of hedgehog pathway genes in epithelial cancers
(Bilkent University, 2006)The Hedgehog (Hh) signaling pathway has been investigated in many cancer types and shown to have important effects, but not effectively studied in breast, colon and liver cancers. In this study, gene expression profile ... -
Genetic and epigenetic effect of estrogen on mesenchymal stem cell maintenance and differentiation
(Bilkent University, 2013)Mesenchymal stem cells (MSCs) have the potential to differentiate into multiple cell types and immune privileged characteristics. These features make MSCs a hope in tissue engineering and cell based treatment ... -
Identification of genes induced by BRCA1 in breast cancer cells
(Bilkent University, 2002)Inherited mutations of the BRCA1 gene predispose to cancer of the breast, ovaries and other organs. The BRCA1 protein product is implicated in the maintenance of chromosomal integrity as BRCA1-deficient cells display ... -
Metastasis suppressor genes and proteins in non-melanoma skin cancers
(Bilkent University, 2014-09)Skin cancers are the most common cancer in human population. They are practically divided into two major group; melanoma and non-melanoma skin cancer (NMSC). NMSC often refers to two common neoplasms; cutaneous squamous ... -
Polymorphisms in P21 (CODON 31) and P53 (CODON 72) : association with breast cancer susceptibility in the Turkish and Greek populations
(Bilkent University, 2003)The aim of this study was to investigate the potential association of p53 codon 72 and/or p21 codon 31 polymorphisms with increased susceptibility for breast cancer either independently or combined in the Turkish and ... -
Polymorphisms of Glutathione S- transferase genes (GSTM1, GSTP1, and GSTT1) and breast cancer susceptibility in the Turkish population
(Bilkent University, 2002)The potential association between the Glutathione S- transferase genes GSTM1, GSTT1, GSTP1 and breast cancer susceptibility was investigated in a case control study of 264 female patients and 233 age-matched controls in ... -
Unmasking of epigenetically silenced genes and identification of transgelin as a potential methylation biomarker in breast cancer
(Bilkent University, 2015-11)Tumor suppressor genes (TSG) are frequently silenced in cancer by epigenetic mechanisms, including promoter DNA hypermethylation and repressive chromatin formation by means of histone deacetylation. 5-aza-2'-deoxycytidine ... -
The use of nanoparticle labeling in cellular tracking
(Bilkent University, 2015-09)Adult stem cells (ASCs) are a population of multipotent cells which have ability of self-renewal and tissue regeneration. Due to their protective and restorative roles, ASCs become candidate for cellular therapies. Some ...
