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Genetic analysis of Smad2 gene in hepatocellular carcinoma
(Bilkent University, 1998)Hepatocellular carcinoma is one of the most malignant cancers and is the most frequent one in some regions in the world. Although it is a multistage disease, its genetic composition is not well understood. TGF(3 is shown ... -
Genetic analysis of Smad4 gene in TGF-Beta signalling pathway in human liver cancer
(Bilkent University, 1998)HCC is a multistep genetic disease in which many genomic changes occur as a result of uncontrolled proliferation of hepatocytes. Molecular events leading to HCC is still unclear. Until now, neither an oncogene nor a tumor ...