Advisors
Now showing items 1-6 of 6
-
Combinatorial targeting of PI3K and MAPK pathways by miR-564 to inhibit proliferation and invasion in breast cancer
(Bilkent University, 2016-07)Breast cancer is among most common malignant tumors worldwide and one of the deadliest cancer types among women. Like other cancer types, dysregulation of signaling pathways is the major cause of uncontrolled cell ... -
Elucidating the mechanisms of T-DM1 resistance in in vitro models of HER2 overexpressing breast cancer
(Bilkent University, 2016-09)Despite the presence of plethora of anti-cancer therapeutics with a variety of different mechanisms of action, it is still not possible to completely eradicate cancer due largely to the occurrence of refractory tumors even ... -
Identification of long non-coding RNAs overcoming tamoxifen resistance in estrogen receptor alpha positive breast cancer
(Bilkent University, 2017-09)Most of the breast cancer incidences all over the world fall into Estrogen Receptor alpha (ERα)-positive breast cancer subtype, which are treated with endocrine therapy. Tamoxifen, a selective ER modulator drug, is the ... -
Identifying and targeting coding/non-coding molecular switches regulating drug resistance and metastasis in breast cancer
(Bilkent University, 2017-09)Breast cancer is the second most common cancer and the leading cause of cancer associated deaths in women worldwide. Despite the availability of large number and various types of therapy agents which are effective in ... -
miRNA-mRNA interaction network regulating chemotherapy resistance in triple negative breast cancer
(Bilkent University, 2019-06)Triple negative breast cancer (TNBC) is the most aggressive breast cancer subtype, lacking the expression of the estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER2). ... -
Targeting mirna-protein regulatory networks to enhance chemotherapy response in BRCA1-mutated TNBCs
(Bilkent University, 2016-09)Breast cancer is the second most common cancer and the leading cause of cancer associated deaths in women worldwide. Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer. BRCA1-mutated TNBC ...
